Understanding Pleural Mesothelioma: Symptoms, Risk Factors, and Treatment Options With A New Research In 2024

Pleural mesothelioma

Pleural mesothelioma is the most common form of cancer affecting the mesothelium, the protective membrane around your lungs, heart, and abdomen. While rare, this cancer can progress quickly, making it crucial to be aware of the symptoms and risk factors. In this article, we explore the symptoms and risk factors for pleural mesothelioma, as well as how it’s diagnosed, staged, and treated.

What is Pleural Mesothelioma?

Pleural mesothelioma is a rare type of lung cancer primarily caused by workplace asbestos exposure. It affects the mesothelial cells within the pleura, the lining of your lungs, creating malignant tumors. Although there are approximately 3,000 new cases of mesothelioma reported annually in the United States, the overall numbers have been declining due to reduced asbestos exposure.

Despite the decreasing incidence, pleural mesothelioma is an aggressive cancer that requires prompt diagnosis and treatment. Understanding the common risk factors and symptoms is vital for early detection and effective management.

Symptoms of Pleural Mesothelioma

The symptoms of pleural mesothelioma may not appear until 30 to 50 years after asbestos exposure. Early stages may be asymptomatic, but advanced stages can present the following symptoms:

  • Chronic dry cough
  • Shortness of breath
  • Chest pain, potentially indicating fluid accumulation (pleural effusion)
  • Fatigue
  • Difficulty swallowing
  • Persistent sensation of something stuck in your throat
  • Lower back pain
  • Fever
  • Swelling of the face and arms
  • Appetite loss
  • Unintentional weight loss

If you experience these symptoms, especially with known asbestos exposure, consult your doctor immediately. Frequent unexplained pneumonia also warrants a medical check-up.

Risk Factors for Pleural Mesothelioma

The primary risk factor for pleural mesothelioma is previous asbestos exposure, particularly in the workplace. According to the American Lung Association, about 8 out of every 10 mesothelioma patients had a history of asbestos exposure. Occupations with higher asbestos exposure risk include:

  • Insulators
  • Construction workers
  • Electricians
  • Miners
  • Millers
  • Pipefitters
  • Plumbers
  • Firefighters

The risk increases with the duration and amount of asbestos exposure. Other risk factors include:

  • Inherited genetic mutations (in about 1% of cases)
  • Advanced age (average onset at 72 years)
  • Childhood radiation therapy

Diagnosing Pleural Mesothelioma

Diagnosis involves imaging tests such as X-rays or CT scans to detect pleural thickening, pleural plaques, or pleural effusion. If mesothelioma is suspected, further imaging and biopsies are conducted to confirm the diagnosis and identify the cancer type. Mesothelioma cells are classified as:

  • Epithelioid (more than 50% of cases, best prognosis)
  • Sarcomatoid
  • Biphasic/mixed (combination of both)

Staging of Pleural Mesothelioma

The staging of pleural mesothelioma helps determine the treatment approach:

  • Stage IA: Localized to pleura, possibly involving the diaphragm, no lymph node spread.
  • Stage IB: Spread to diaphragm and chest wall, no lymph node involvement.
  • Stage II: Regional spread to diaphragm, chest wall, lungs, possibly lymph nodes on one side.
  • Stage IIIA: May involve fatty tissues and deeper chest layers, still potentially surgically removable.
  • Stage IIIB: Inoperable, has spread to other organs and deeper tissues but not distant body parts.
  • Stage IV: Spread to lymph nodes, distant organs (liver, bones, abdomen).

Treatment for Pleural Mesothelioma

Treatment options may include:

  • Chemotherapy: To shrink and control cancer cells.
  • Targeted therapies: Directly attacking cancer cells.
  • Immunotherapy: Utilizing the immune system to fight cancer.
  • Surgery: Removing the pleura (pleurectomy) or parts of the lung.
  • Thoracentesis: Removing fluid buildup to improve quality of life, though it doesn’t eliminate cancer cells.

Outlook for Pleural Mesothelioma

The American Cancer Society reports 5-year survival rates based on data from 2010-2016:

  • Localized (Stages IA and IB): 18%
  • Regional (Stages II, IIIA, and IIIB): 12%
  • Distant (Stage IV): 7%

Your overall prognosis depends on factors such as age, health, and treatment advances. Early diagnosis improves outcomes, so discussing all options with your doctor is essential.


Pleural mesothelioma, while rare, is an aggressive cancer primarily linked to asbestos exposure. Early detection and prompt treatment are crucial. If you have symptoms or a history of asbestos exposure, seek medical advice immediately to explore your options and improve your quality of life.

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